Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch Its Receptor Specificity
Of the factors governing human-to-human transmission of the highly pathogenic avian-adapted H5N1 virus, the most critical is the acquisition of mutations on the viral hemagglutinin (HA) to “quantitatively switch” its binding from avian to human glycan receptors. Here, we describe a structural framew...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2014
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| Online Access: | http://hdl.handle.net/1721.1/89056 https://orcid.org/0000-0002-1288-9965 https://orcid.org/0000-0002-2085-7840 https://orcid.org/0000-0002-6528-0125 |