EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism

EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism

Tumor cells often subvert normal regulatory mechanisms of signal transduction. This study shows this principle by studying yet uncharacterized mutants of the epidermal growth factor receptor (EGFR) previously identified in glioblastoma multiforme, which is the most aggressive brain tumor in adults....

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Bibliographic Details
Main Authors: Pines, G, Zwang, Y, Yarden, Y, Huang, P. H., White, Forest M.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/89069
https://orcid.org/0000-0002-1545-1651

Internet

http://hdl.handle.net/1721.1/89069
https://orcid.org/0000-0002-1545-1651

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