EGFRvIV: a previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism

Tumor cells often subvert normal regulatory mechanisms of signal transduction. This study shows this principle by studying yet uncharacterized mutants of the epidermal growth factor receptor (EGFR) previously identified in glioblastoma multiforme, which is the most aggressive brain tumor in adults....

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书目详细资料
Main Authors: Pines, G, Zwang, Y, Yarden, Y, Huang, P. H., White, Forest M.
其他作者: Massachusetts Institute of Technology. Department of Biological Engineering
格式: 文件
语言:en_US
出版: Nature Publishing Group 2014
在线阅读:http://hdl.handle.net/1721.1/89069
https://orcid.org/0000-0002-1545-1651