Composability of regulatory sequences controlling transcription and translation in Escherichia coli

The inability to predict heterologous gene expression levels precisely hinders our ability to engineer biological systems. Using well-characterized regulatory elements offers a potential solution only if such elements behave predictably when combined. We synthesized 12,563 combinations of common pro...

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Bibliographic Details
Main Authors: Kosuri, Sriram, Goodman, Daniel Bryan, Cambray, Guillaume, Mutalik, Vivek K., Gao, Yuan, Arkin, Adam P., Endy, Drew, Church, George M.
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/89095
https://orcid.org/0000-0003-3759-6883

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