Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC

Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide–MHC (pMHC), showing peptide specificity...

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Bibliographic Details
Main Authors: Hoerter, John A. H., Brzostek, Joanna, Artyomov, Maxim N., Abel, Steven M., Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M., Chakraborty, Arup K., Gould, Keith G., Gascoigne, Nicholas R. J.
Other Authors: Institute for Medical Engineering and Science
Format: Article
Language:en_US
Published: Rockefeller University Press 2014
Online Access:http://hdl.handle.net/1721.1/89124
https://orcid.org/0000-0003-1268-9602

Internet

http://hdl.handle.net/1721.1/89124
https://orcid.org/0000-0003-1268-9602

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