Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC
Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide–MHC (pMHC), showing peptide specificity...
Main Authors: | Hoerter, John A. H., Brzostek, Joanna, Artyomov, Maxim N., Abel, Steven M., Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M., Chakraborty, Arup K., Gould, Keith G., Gascoigne, Nicholas R. J. |
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Other Authors: | Institute for Medical Engineering and Science |
Format: | Article |
Language: | en_US |
Published: |
Rockefeller University Press
2014
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Online Access: | http://hdl.handle.net/1721.1/89124 https://orcid.org/0000-0003-1268-9602 |
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