The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

The oncogenic transcription factor TAL1/SCL is aberrantly expressed in 60% of cases of human T cell acute lymphoblastic leukemia (T-ALL) and initiates T-ALL in mouse models. By performing global microRNA (miRNA) expression profiling after depletion of TAL1, together with genome-wide analysis of TAL1...

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Những tác giả chính: Mansour, Marc R., Sanda, Takaomi, Lawton, Lee N., Li, Xiaoyu, Kreslavsky, Taras, Novina, Carl D., Brand, Marjorie, Gutierrez, Alejandro, Kelliher, Michelle A., Jamieson, Catriona H. M., von Boehmer, Harald, Young, Richard A., Look, A. Thomas
Tác giả khác: Massachusetts Institute of Technology. Department of Biology
Định dạng: Bài viết
Ngôn ngữ:en_US
Được phát hành: Rockefeller University Press 2014
Truy cập trực tuyến:http://hdl.handle.net/1721.1/89125
https://orcid.org/0000-0001-8855-8647

Internet

http://hdl.handle.net/1721.1/89125
https://orcid.org/0000-0001-8855-8647

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