Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

Spindle assembly checkpoint robustness requires Tpr-mediated regulation of Mad1/Mad2 proteostasis

Tpr is a conserved nuclear pore complex (NPC) protein implicated in the spindle assembly checkpoint (SAC) by an unknown mechanism. Here, we show that Tpr is required for normal SAC response by stabilizing Mad1 and Mad2 before mitosis. Tpr coimmunoprecipitated with Mad1 and Mad2 (hereafter designated...

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Bibliographic Details
Main Authors: Schweizer, Nina, Ferras, Cristina, Kern, David Matthew, Logarinho, Elsa, Maiato, Helder, Cheeseman, Iain M
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Rockefeller University Press 2014
Online Access:http://hdl.handle.net/1721.1/89126
https://orcid.org/0000-0002-3829-5612
https://orcid.org/0000-0001-8529-9045

Internet

http://hdl.handle.net/1721.1/89126
https://orcid.org/0000-0002-3829-5612
https://orcid.org/0000-0001-8529-9045

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