Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus

Gene regulation relies on transcription factors (TFs) exploring the nucleus searching their targets. So far, most studies have focused on how fast TFs diffuse, underestimating the role of nuclear architecture. We implemented a single-molecule tracking assay to determine TFs dynamics. We found that c...

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Bibliographic Details
Main Authors: Izeddin, Ignacio, Recamier, Vincent, Bosanac, Lana, Cisse, Ibrahim, Boudarene, Lydia, Dugast-Darzacq, Claire, Proux, Florence, Benichou, Olivier, Voituriez, Raphaël, Bensaude, Olivier, Dahan, Maxime, Darzacq, Xavier
Other Authors: Massachusetts Institute of Technology. Department of Physics
Format: Article
Language:en_US
Published: eLife Sciences Publications, Ltd. 2014
Online Access:http://hdl.handle.net/1721.1/89167
https://orcid.org/0000-0002-8764-1809

Internet

http://hdl.handle.net/1721.1/89167
https://orcid.org/0000-0002-8764-1809

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