Addressing Genetic Tumor Heterogeneity through Computationally Predictive Combination Therapy

Recent tumor sequencing data suggest an urgent need to develop a methodology to directly address intratumoral heterogeneity in the design of anticancer treatment regimens. We use RNA interference to model heterogeneous tumors, and demonstrate successful validation of computational predictions for ho...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Zhao, Boyang, Pritchard, Justin R., Hemann, Michael, Lauffenburger, Douglas A
Бусад зохиолчид: Massachusetts Institute of Technology. Computational and Systems Biology Program
Формат: Өгүүллэг
Хэл сонгох:en_US
Хэвлэсэн: American Association for Cancer Research 2014
Онлайн хандалт:http://hdl.handle.net/1721.1/89180
https://orcid.org/0000-0003-4610-1707