Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

Muscle-Specific SIRT1 Gain-of-Function Increases Slow-Twitch Fibers and Ameliorates Pathophysiology in a Mouse Model of Duchenne Muscular Dystrophy

SIRT1 is a metabolic sensor and regulator in various mammalian tissues and functions to counteract metabolic and age-related diseases. Here we generated and analyzed mice that express SIRT1 at high levels specifically in skeletal muscle. We show that SIRT1 transgenic muscle exhibits a fiber shift fr...

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Bibliographic Details
Main Authors: Chalkiadaki, Angeliki, Igarashi, Masaki, Nasamu, Armiyaw Sebastian, Knezevic, Jovana, Guarente, Leonard Pershing
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/89216
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0003-2762-4844
https://orcid.org/0000-0003-1160-3969

Internet

http://hdl.handle.net/1721.1/89216
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0003-2762-4844
https://orcid.org/0000-0003-1160-3969

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