Mechanism of a flow-gated angiogenesis switch: early signaling events at cell–matrix and cell–cell junctions

A bias towards angiogenesis from the venous circulation has long been known, but its cause remains unclear. Here we explore the possibility that high interstitial pressure in tumors and the resultant net filtration pressure gradient that would induce flow from the interstitium into the venous circul...

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Detalhes bibliográficos
Principais autores: Vickerman, Vernella, Kamm, Roger Dale
Outros Autores: Massachusetts Institute of Technology. Department of Biological Engineering
Formato: Artigo
Idioma:en_US
Publicado em: Royal Society of Chemistry 2014
Acesso em linha:http://hdl.handle.net/1721.1/89235
https://orcid.org/0000-0002-7232-304X