Neddylation dysfunction in Alzheimer's disease
Ubiquitin-dependent proteolysis is a major mechanism that downregulates misfolded proteins or those that have finished a programmed task. In the last two decades, neddylation has emerged as a major regulatory pathway for ubiquitination. Central to the neddylation pathway is the amyloid precursor pro...
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| Format: | Article |
| Language: | en_US |
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John Wiley & Sons, Inc
2014
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| Online Access: | http://hdl.handle.net/1721.1/89400 https://orcid.org/0000-0002-3854-5968 |
| _version_ | 1811094299879669760 |
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| author | Chen, Yuzhi Neve, Rachael L. Liu, Helena |
| author2 | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences |
| author_facet | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Chen, Yuzhi Neve, Rachael L. Liu, Helena |
| author_sort | Chen, Yuzhi |
| collection | MIT |
| description | Ubiquitin-dependent proteolysis is a major mechanism that downregulates misfolded proteins or those that have finished a programmed task. In the last two decades, neddylation has emerged as a major regulatory pathway for ubiquitination. Central to the neddylation pathway is the amyloid precursor protein (APP)-binding protein APP-BP1, which together with Uba3, plays an analogous role to the ubiquitin-activating enzyme E1 in nedd8 activation. Activated nedd8 covalently modifies and activates a major class of ubiquitin ligases called Cullin-RING ligases (CRLs). New evidence suggests that neddylation also modifies Type-1 transmembrane receptors such as APP. Here we review the functions of neddylation and summarize evidence suggesting that dysfunction of neddylation is involved in Alzheimer's disease. |
| first_indexed | 2024-09-23T15:57:50Z |
| format | Article |
| id | mit-1721.1/89400 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:57:50Z |
| publishDate | 2014 |
| publisher | John Wiley & Sons, Inc |
| record_format | dspace |
| spelling | mit-1721.1/894002022-10-02T05:23:28Z Neddylation dysfunction in Alzheimer's disease Chen, Yuzhi Neve, Rachael L. Liu, Helena Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Massachusetts Institute of Technology. Department of Materials Science and Engineering Neve, Rachael L. Liu, Helena Ubiquitin-dependent proteolysis is a major mechanism that downregulates misfolded proteins or those that have finished a programmed task. In the last two decades, neddylation has emerged as a major regulatory pathway for ubiquitination. Central to the neddylation pathway is the amyloid precursor protein (APP)-binding protein APP-BP1, which together with Uba3, plays an analogous role to the ubiquitin-activating enzyme E1 in nedd8 activation. Activated nedd8 covalently modifies and activates a major class of ubiquitin ligases called Cullin-RING ligases (CRLs). New evidence suggests that neddylation also modifies Type-1 transmembrane receptors such as APP. Here we review the functions of neddylation and summarize evidence suggesting that dysfunction of neddylation is involved in Alzheimer's disease. National Institutes of Health (U.S.) (NIH/NIA RO1 AG034980) 2014-09-09T19:13:42Z 2014-09-09T19:13:42Z 2012-11 2012-02 Article http://purl.org/eprint/type/JournalArticle 15821838 http://hdl.handle.net/1721.1/89400 Chen, Yuzhi, Rachael L. Neve, and Helena Liu. “Neddylation Dysfunction in Alzheimer’s Disease.” J. Cell. Mol. Med. 16, no. 11 (October 29, 2012): 2583–2591. https://orcid.org/0000-0002-3854-5968 en_US http://dx.doi.org/10.1111/j.1582-4934.2012.01604.x Journal of Cellular and Molecular Medicine Creative Commons Attribution http://creativecommons.org/licenses/by/3.0/ application/pdf John Wiley & Sons, Inc Wiley Blackwell |
| spellingShingle | Chen, Yuzhi Neve, Rachael L. Liu, Helena Neddylation dysfunction in Alzheimer's disease |
| title | Neddylation dysfunction in Alzheimer's disease |
| title_full | Neddylation dysfunction in Alzheimer's disease |
| title_fullStr | Neddylation dysfunction in Alzheimer's disease |
| title_full_unstemmed | Neddylation dysfunction in Alzheimer's disease |
| title_short | Neddylation dysfunction in Alzheimer's disease |
| title_sort | neddylation dysfunction in alzheimer s disease |
| url | http://hdl.handle.net/1721.1/89400 https://orcid.org/0000-0002-3854-5968 |
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