A conserved MCM single-stranded DNA binding element is essential for replication initiation
The ring-shaped MCM helicase is essential to all phases of DNA replication. The complex loads at replication origins as an inactive double-hexamer encircling duplex DNA. Helicase activation converts this species to two active single hexamers that encircle single-stranded DNA (ssDNA). The molecular d...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
eLife Sciences Publications, Ltd.
2014
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| Online Access: | http://hdl.handle.net/1721.1/89402 https://orcid.org/0000-0002-2876-610X |