Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

Impaired Autophagy in the Lipid-Storage Disorder Niemann-Pick Type C1 Disease

Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid-storage disorders is not clear. Here, we show defective autophagy in Niemann-Pick type C1 (NPC1) disease a...

Full description

Bibliographic Details
Main Authors: Sarkar, Sovan, Carroll, Bernadette, Buganim, Yosef, Maetzel, Dorothea, Ng, Alex H. M., Cassady, John P., Cohen, Malkiel A., Chakraborty, Souvik, Wang, Haoyi, Spooner, Eric, Ploegh, Hidde, Gsponer, Joerg, Korolchuk, Viktor I., Jaenisch, Rudolf
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/90306
https://orcid.org/0000-0002-1090-6071

Internet

http://hdl.handle.net/1721.1/90306
https://orcid.org/0000-0002-1090-6071

Similar Items