Mechanotransduction of fluid stresses governs 3D cell migration

Mechanotransduction of fluid stresses governs 3D cell migration

Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from the tumor core. Tumor-associated interstitial flow (IF) at a rate of ∼3 µm/s has been shown to induce cell migration in the upstream direction (rheotaxis). However, the molecular biophysical mechanism...

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Bibliographic Details
Main Authors: Polacheck, William J., German, Alexandra E., Mammoto, Akiko, Ingber, Donald E., Kamm, Roger Dale
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/90327
https://orcid.org/0000-0003-2728-0746
https://orcid.org/0000-0002-7232-304X

Internet

http://hdl.handle.net/1721.1/90327
https://orcid.org/0000-0003-2728-0746
https://orcid.org/0000-0002-7232-304X

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