Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells
Valency requirements for B cell activation upon antigen encounter are poorly understood. OB1 transnuclear B cells express an IgG1 B cell receptor (BCR) specific for ovalbumin (OVA), the epitope of which can be mimicked using short synthetic peptides to allow antigen-specific engagement of the BCR. B...
Main Authors: | Avalos, Ana M., Bilate, Angelina M., Witte, Martin D., Tai, Albert K., He, Jiang, Frushicheva, Maria P., Thill, Peter Daniel, Meyer-Wentrup, Friederike, Theile, Christopher S., Chakraborty, Arup K., Zhuang, Xiaowei, Ploegh, Hidde |
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Other Authors: | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
Format: | Article |
Language: | en_US |
Published: |
Rockefeller University Press
2014
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Online Access: | http://hdl.handle.net/1721.1/90353 https://orcid.org/0000-0001-6259-8800 https://orcid.org/0000-0002-7487-8858 https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0002-1090-6071 |
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