De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling
Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)–scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...
Main Authors: | , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | en_US |
Published: |
Public Library of Science
2014
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Online Access: | http://hdl.handle.net/1721.1/90951 https://orcid.org/0000-0003-3599-0297 https://orcid.org/0000-0002-9703-1780 https://orcid.org/0000-0002-2988-0537 |