De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

Malignant carcinomas that recur following therapy are typically de-differentiated and multidrug resistant (MDR). De-differentiated cancer cells acquire MDR by up-regulating reactive oxygen species (ROS)–scavenging enzymes and drug efflux pumps, but how these genes are up-regulated in response to de-...

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Bibliographic Details
Main Authors: Del Vecchio, Catherine A., Feng, Yuxiong, Sokol, Ethan Samuel, Tillman, Erik J., Sanduja, Sandhya, Reinhardt, Ferenc, Gupta, Piyush
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/90951
https://orcid.org/0000-0003-3599-0297
https://orcid.org/0000-0002-9703-1780
https://orcid.org/0000-0002-2988-0537

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