Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

Histone Deacetylase Inhibitors Impair the Elimination of HIV-Infected Cells by Cytotoxic T-Lymphocytes

Resting memory CD4[superscript +] T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, and panobinostat have been shown to induce HIV expression in these resting cells...

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Bibliographic Details
Main Authors: Jones, Richard Bradley, O'Connor, Rachel, Mueller, Stefanie, Foley, Maria Hottelet, Karel, Dan, Lichterfeld, Mathias, Kovacs, Colin, Ostrowski, Mario A., Trocha, Alicja, Walker, Bruce D., Szeto, Gregory, Irvine, Darrell J
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/90954
https://orcid.org/0000-0001-7604-1333
https://orcid.org/0000-0003-4083-335X

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http://hdl.handle.net/1721.1/90954
https://orcid.org/0000-0001-7604-1333
https://orcid.org/0000-0003-4083-335X

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