Helicobacter hepaticus Infection Promotes Hepatitis and Preneoplastic Foci in Farnesoid X Receptor (FXR) Deficient Mice

Helicobacter hepaticus Infection Promotes Hepatitis and Preneoplastic Foci in Farnesoid X Receptor (FXR) Deficient Mice

Farnesoid X receptor (FXR) is a nuclear receptor that regulates bile acid metabolism and transport. Mice lacking expression of FXR (FXR KO) have a high incidence of foci of cellular alterations (FCA) and liver tumors. Here, we report that Helicobacter hepaticus infection is necessary for the develop...

Full description

Bibliographic Details
Main Authors: Swennes, Alton G., Sheh, Alexander, Parry, Nicola M. A., Muthupalani, Sureshkumar, Lertpiriyapong, Kvin, Garcia, Alexis, Fox, James G.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/90998
https://orcid.org/0000-0001-9307-6116

Internet

http://hdl.handle.net/1721.1/90998
https://orcid.org/0000-0001-9307-6116

Similar Items