In Vitro-In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery

In Vitro-In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery

A significant challenge in the development of clinically viable siRNA delivery systems is a lack of in vitro–in vivo translatability: many delivery vehicles that are initially promising in cell culture do not retain efficacy in animals. Despite its importance, little information exists on the predic...

Full description

Bibliographic Details
Main Authors: Matthews, Jonathan, Chang, Philip H., Niroui, Farnaz, Severgnini, Mariano, Whitehead, Kathryn Ann, Dorkin, Joseph Robert, Anderson, Daniel Griffith
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/91139
https://orcid.org/0000-0002-0100-7824
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0002-2332-2657

Internet

http://hdl.handle.net/1721.1/91139
https://orcid.org/0000-0002-0100-7824
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0002-2332-2657

Similar Items