Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

Background—Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, the appropriate magnitude and timing of interventions are largely unknown, in...

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Bibliographic Details
Main Authors: Majmudar, Maulik D., Keliher, Edmund J., Heidt, Timo, Leuschner, Florian, Truelove, Jessica, Sena, Brena F., Gorbatov, Rostic, Iwamoto, Yoshiko, Dutta, Partha, Wojtkiewicz, Gregory, Courties, Gabriel, Sebas, Matt, Borodovsky, Anna, Fitzgerald, Kevin, Nolte, Marc W., Dickneite, Gerhard, Chen, John W., Anderson, Daniel Griffith, Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: American Heart Association 2014
Online Access:http://hdl.handle.net/1721.1/91250
https://orcid.org/0000-0001-5629-4798

Internet

http://hdl.handle.net/1721.1/91250
https://orcid.org/0000-0001-5629-4798

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