Lipidoid-Coated Iron Oxide Nanoparticles for Efficient DNA and siRNA delivery

The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to their broad clinical application. Here we develop a magnetic nucleic acid delivery system composed of iron oxide nanoparticles and cationic lipid-like materials termed lipidoids. Coated nanoparticles are...

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Bibliographic Details
Main Authors: Jiang, Shan, Eltoukhy, Ahmed A., Anderson, Daniel Griffith, Love, Kevin T, Langer, Robert S
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: American Chemical Society (ACS) 2014
Online Access:http://hdl.handle.net/1721.1/91255
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0003-4255-0492