Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/...

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Bibliographic Details
Main Authors: Dong, Yizhou, Love, Kevin T., Dorkin, Joseph Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman, Yin, Hao, Chen, Yi, Vegas, Arturo, Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten, Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Kotelianski, Victor E., Langer, Robert, Anderson, Daniel Griffith
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/91468
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0002-4680-3832
https://orcid.org/0000-0001-5786-0659
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-6898-3793
https://orcid.org/0000-0003-3298-6022
https://orcid.org/0000-0001-9522-8208
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/91468
https://orcid.org/0000-0002-2100-1171
https://orcid.org/0000-0002-4680-3832
https://orcid.org/0000-0001-5786-0659
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-6898-3793
https://orcid.org/0000-0003-3298-6022
https://orcid.org/0000-0001-9522-8208
https://orcid.org/0000-0003-4255-0492

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