Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
National Academy of Sciences (U.S.)
2014
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| Online Access: | http://hdl.handle.net/1721.1/91468 https://orcid.org/0000-0002-2100-1171 https://orcid.org/0000-0002-4680-3832 https://orcid.org/0000-0001-5786-0659 https://orcid.org/0000-0001-5629-4798 https://orcid.org/0000-0001-6898-3793 https://orcid.org/0000-0003-3298-6022 https://orcid.org/0000-0001-9522-8208 https://orcid.org/0000-0003-4255-0492 |