Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

Reductively metabolized glutamine is a major cellular carbon source for fatty acid synthesis during hypoxia or when mitochondrial respiration is impaired. Yet, a mechanistic understanding of what determines reductive metabolism is missing. Here we identify several cellular conditions where the α-ket...

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Bibliographic Details
Main Authors: Fendt, Sarah-Maria, Bell, Eric L., Mayers, Jared R., Vokes, Natalie I., Stephanopoulos, Gregory, Keibler, Mark Andrew, Wasylenko, Thomas Michael, Guarente, Leonard Pershing, Vander Heiden, Matthew G., Olenchock, Benjamin
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/91505
https://orcid.org/0000-0002-8956-5117
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0001-6909-4568

Internet

http://hdl.handle.net/1721.1/91505
https://orcid.org/0000-0002-8956-5117
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0001-6909-4568

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