Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

Metformin inhibits cancer cell proliferation, and epidemiology studies suggest an association with increased survival in patients with cancer taking metformin; however, the mechanism by which metformin improves cancer outcomes remains controversial. To explore how metformin might directly affect can...

Full description

Bibliographic Details
Main Authors: Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Wirth, Gregory J., Fiske, Brian Prescott, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfred, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C., Guarente, Leonard Pershing, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: American Association for Cancer Research 2014
Online Access:http://hdl.handle.net/1721.1/91508
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0001-6909-4568
https://orcid.org/0000-0003-0701-5275

Internet

http://hdl.handle.net/1721.1/91508
https://orcid.org/0000-0002-8607-1787
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-5410-6543
https://orcid.org/0000-0003-4064-2510
https://orcid.org/0000-0001-6909-4568
https://orcid.org/0000-0003-0701-5275

Similar Items