Clioquinol promotes the degradation of metal-dependent amyloid-β  (Aβ) oligomers to restore endocytosis and ameliorate Aβ  toxicity

Clioquinol promotes the degradation of metal-dependent amyloid-β  (Aβ) oligomers to restore endocytosis and ameliorate Aβ  toxicity

Alzheimer’s disease (AD) is a common, progressive neurodegenerative disorder without effective disease-modifying therapies. The accumulation of amyloid-β peptide (Aβ) is associated with AD. However, identifying new compounds that antagonize the underlying cellular pathologies caused by Aβ has been h...

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Bibliographic Details
Main Authors: Matlack, Kent E. S., Tardiff, Daniel F., Narayan, Priyanka, Hamamichi, Shusei, Caldwell, Kim A., Caldwell, Guy A., Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: National Academy of Sciences (U.S.) 2014
Online Access:http://hdl.handle.net/1721.1/91531
https://orcid.org/0000-0003-1307-882X

Internet

http://hdl.handle.net/1721.1/91531
https://orcid.org/0000-0003-1307-882X

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