Conserved electron donor complex Dre2-Tah18 is required for ribonucleotide reductase metallocofactor assembly and DNA synthesis
Eukaryotic ribonucleotide reductases (RNRs) require a diferric-tyrosyl radical (Fe[III over 2]-Y•) cofactor to produce deoxynucleotides essential for DNA replication and repair. This metallocofactor is an important target of RNR-based therapeutics, although mechanisms of in vivo cofactor assembly, i...
| Hauptverfasser: | , , , , , , |
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| Format: | Artikel |
| Sprache: | en_US |
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National Academy of Sciences (U.S.)
2014
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| Online Zugang: | http://hdl.handle.net/1721.1/91532 https://orcid.org/0000-0001-8076-4489 |