Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of met...

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Bibliographic Details
Main Authors: Luengo, Alba, Sullivan, Lucas Bryan, Vander Heiden, Matthew G.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: BioMed Central Ltd 2014
Online Access:http://hdl.handle.net/1721.1/91581
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0002-6745-8222