Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of met...

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Podrobná bibliografie
Hlavní autoři: Luengo, Alba, Sullivan, Lucas Bryan, Vander Heiden, Matthew G.
Další autoři: Massachusetts Institute of Technology. Department of Biology
Médium: Článek
Jazyk:English
Vydáno: BioMed Central Ltd 2014
On-line přístup:http://hdl.handle.net/1721.1/91581
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-4236-0229
https://orcid.org/0000-0002-6745-8222