Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy
Metformin has been a first-line treatment for type II diabetes mellitus for decades and is the most widely prescribed antidiabetic drug. Retrospective studies have found that metformin treatment is associated with both reduced cancer diagnoses and cancer-related deaths. Despite the prevalence of met...
Main Authors: | Luengo, Alba, Sullivan, Lucas Bryan, Vander Heiden, Matthew G. |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | English |
Published: |
BioMed Central Ltd
2014
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Online Access: | http://hdl.handle.net/1721.1/91581 https://orcid.org/0000-0002-6702-4192 https://orcid.org/0000-0002-4236-0229 https://orcid.org/0000-0002-6745-8222 |
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