Operator Sequence Alters Gene Expression Independently of Transcription Factor Occupancy in Bacteria

A canonical quantitative view of transcriptional regulation holds that the only role of operator sequence is to set the probability of transcription factor binding, with operator occupancy determining the level of gene expression. In this work, we test this idea by characterizing repression in vivo...

Full description

Bibliographic Details
Main Authors: Garcia, Hernan G., Boedicker, James Q., Osborne, Melisa, Gelles, Jeff, Kondev, Jane, Phillips, Rob, Sanchez Ferro, Alvaro
Other Authors: Massachusetts Institute of Technology. Department of Physics
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/91648
https://orcid.org/0000-0002-8568-7432