A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

A Nanoparticle-Based Combination Chemotherapy Delivery System for Enhanced Tumor Killing by Dynamic Rewiring of Signaling Pathways

Exposure to the EGFR (epidermal growth factor receptor) inhibitor erlotinib promotes the dynamic rewiring of apoptotic pathways, which sensitizes cells within a specific period to subsequent exposure to the DNA-damaging agent doxorubicin. A critical challenge for translating this therapeutic network...

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Bibliographic Details
Main Authors: Morton, Stephen Winford, Lee, Michael J., Deng, Zhou J., Siouve, Elise, Shopsowitz, Kevin, Shah, Nisarg J., Dreaden, Erik, Yaffe, Michael B, Hammond, Paula T
Other Authors: Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
Format: Article
Language:en_US
Published: American Association for the Advancement of Science (AAAS) 2014
Online Access:http://hdl.handle.net/1721.1/91686
https://orcid.org/0000-0002-4954-8443
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0003-1727-5732
https://orcid.org/0000-0003-3988-0837

Internet

http://hdl.handle.net/1721.1/91686
https://orcid.org/0000-0002-4954-8443
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0003-1727-5732
https://orcid.org/0000-0003-3988-0837

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