Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks
Crosstalk and complexity within signaling pathways and their perturbation by oncogenes limit component-by-component approaches to understanding human disease. Network analysis of how normal and oncogenic signaling can be rewired by drugs may provide opportunities to target tumors with high specifici...
Main Authors: | Lee, Michael J., Ye, Albert S., Gardino, Alexandra Kate, Heijink, Anne Margriet, Sorger, Peter K., MacBeath, Gavin, Yaffe, Michael B., Sorger, Peter K., Yaffe, Michael B. |
---|---|
Other Authors: | Massachusetts Institute of Technology. Cell Decision Process Center |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2014
|
Online Access: | http://hdl.handle.net/1721.1/91688 https://orcid.org/0000-0002-9547-3251 |
Similar Items
-
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis
by: Gardino, Alexandra K., et al.
Published: (2016) -
UGA Read-Through Artifacts—When Popular Gene Expression Systems Need a pATCH
by: Gavin MacBeath, et al.
Published: (1998-05-01) -
Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
by: Fabian Fröhlich, et al.
Published: (2023-01-01) -
A system-wide investigation of the dynamics of Wnt signaling reveals novel phases of transcriptional regulation.
by: Taranjit S Gujral, et al.
Published: (2010-04-01) -
The times guide to the Industrial Relations Act : workers, managers and the law in Britain/
by: 280381 MacBeath, Innis
Published: (1971)