The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β

The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β

Recognition of the proper start codon on mRNAs is essential for protein synthesis, which requires scanning and involves eukaryotic initiation factors (eIFs) eIF1, eIF1A, eIF2, and eIF5. The carboxyl terminal domain (CTD) of eIF5 stimulates 43S preinitiation complex (PIC) assembly; however, its preci...

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Bibliographic Details
Main Authors: Luna, Rafael E., Arthanari, Haribabu, Hiraishi, Hiroyuki, Nanda, Jagpreet, Martin-Marcos, Pilar, Markus, Michelle A., Akabayov, Barak, Milbradt, Alexander G., Luna, Lunet E., Seo, Hee-Chan, Hyberts, Sven G., Fahmy, Amr, Reibarkh, Mikhail, Miles, David, Hagner, Patrick R., O'Day, Elizabeth M., Yi, Tingfang, Marintchev, Assen, Hinnebusch, Alan G., Lorsch, Jon R., Asano, Katsura, Wagner, Gerhard
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/91690

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http://hdl.handle.net/1721.1/91690

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