Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy
Proliferating tumor cells use aerobic glycolysis to support their high metabolic demands. Paradoxically, increased glycolysis is often accompanied by expression of the lower activity PKM2 isoform, effectively constraining lower glycolysis. Here, we report the discovery of PKM2 activators with a uniq...
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| Materiálatiipa: | Artihkal |
| Giella: | en_US |
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Elsevier
2014
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| Liŋkkat: | http://hdl.handle.net/1721.1/91894 https://orcid.org/0000-0002-6702-4192 |