HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tr...

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Bibliographic Details
Main Authors: Mendillo, Marc L., Santagata, Sandro, Bell, George W., Hu, Rong, Tamimi, Rulla M., Fraenkel, Ernest, Ince, Tan A., Whitesell, Luke, Lindquist, Susan, Koeva, Martina I
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/91912
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0001-7024-0921

Internet

http://hdl.handle.net/1721.1/91912
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0001-9249-8181
https://orcid.org/0000-0001-7024-0921

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