Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls
Decades ago, two nonoverlapping crypt stem cell populations were proposed: Leblond’s Crypt Base Columnar (CBC) cell and Potten’s +4 cell. The identification of CBC markers including Lgr5 has confirmed Leblond’s predictions that CBC cells are anatomically distinct, long-lived stem cells that permanen...
Main Authors: | Barker, Nick, van Oudenaarden, Alexander, Clevers, Hans, van Oudenaarden, Alexander |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2014
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Online Access: | http://hdl.handle.net/1721.1/91960 |
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