Global microRNA depletion suppresses tumor angiogenesis

MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signalin...

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Detalhes bibliográficos
Principais autores: Chen, Sidi, Xue, Yuan, Le, Cong, Bhutkar, Arjun (AJ), Bell, Eric L., Zhang, Feng, Langer, Robert, Sharp, Phillip A., Wu, Xuebing, Ph. D. Massachusetts Institute of Technology
Outros Autores: Massachusetts Institute of Technology. Computational and Systems Biology Program
Formato: Artigo
Idioma:en_US
Publicado em: Cold Spring Harbor Laboratory Press 2014
Acesso em linha:http://hdl.handle.net/1721.1/91982
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-0369-5269
https://orcid.org/0000-0003-4255-0492