Global microRNA depletion suppresses tumor angiogenesis

Global microRNA depletion suppresses tumor angiogenesis

MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly hypoxic but poorly vascularized, suggestive of deficient angiogenesis signalin...

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Bibliographic Details
Main Authors: Chen, Sidi, Xue, Yuan, Le, Cong, Bhutkar, Arjun (AJ), Bell, Eric L., Zhang, Feng, Langer, Robert, Sharp, Phillip A., Wu, Xuebing, Ph. D. Massachusetts Institute of Technology
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press 2014
Online Access:http://hdl.handle.net/1721.1/91982
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-0369-5269
https://orcid.org/0000-0003-4255-0492

Internet

http://hdl.handle.net/1721.1/91982
https://orcid.org/0000-0003-1465-1691
https://orcid.org/0000-0003-0369-5269
https://orcid.org/0000-0003-4255-0492

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