Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs

Most archaea and bacteria use a modified C in the anticodon wobble position of isoleucine tRNA to base pair with A but not with G of the mRNA. This allows the tRNA to read the isoleucine codon AUA without also reading the methionine codon AUG. To understand why a modified C, and not U or modified U,...

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Bibliographic Details
Main Authors: Mandal, Debabrata, Koehrer, Caroline, Su, Dan, Babu, I. Ramesh, Chan, Tsz Yan Clement, Liu, Yuchen, Soll, Dieter, Blum, Paul, Kuwahara, Masayasu, Dedon, Peter C., Rajbhandary, Uttam L.
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Cold Spring Harbor Laboratory Press/RNA Society 2014
Online Access:http://hdl.handle.net/1721.1/91989
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0002-4530-5647
https://orcid.org/0000-0001-8533-2706
https://orcid.org/0000-0001-7940-3459

Internet

http://hdl.handle.net/1721.1/91989
https://orcid.org/0000-0003-0011-3067
https://orcid.org/0000-0002-4530-5647
https://orcid.org/0000-0001-8533-2706
https://orcid.org/0000-0001-7940-3459

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