The Lin28/let-7 Axis Regulates Glucose Metabolism

The Lin28/let-7 Axis Regulates Glucose Metabolism

The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating metabolism. When overexpressed in mice, both Lin28...

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Bibliografische gegevens
Hoofdauteurs: Zhu, Hao, Shyh-Chang, Ng, Segrè, Ayellet V., Shinoda, Gen, Shah, Samar P., Einhorn, William S., Takeuchi, Ayumu, Engreitz, Jesse Michael, Hagan, John P., Kharas, Michael G., Urbach, Achia, Thornton, James E., Triboulet, Robinson, Gregory, Richard I., Altshuler, David, Daley, George Q.
Andere auteurs: Harvard University--MIT Division of Health Sciences and Technology
Formaat: Artikel
Taal:en_US
Gepubliceerd in: Elsevier B.V. 2014
Online toegang:http://hdl.handle.net/1721.1/91991
https://orcid.org/0000-0002-5754-1719

Internet

http://hdl.handle.net/1721.1/91991
https://orcid.org/0000-0002-5754-1719

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