Optimality in the Development of Intestinal Crypts

Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigate the design principles governing the dynamics of these proportions during crypt morphogenesis. Using op...

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Bibliographic Details
Main Authors: Itzkovitz, Shaul Shalev, Blat, Irene C., Clevers, Hans, van Oudenaarden, Alexander, Jacks, Tyler E., van Oudenaarden, Alexander
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/92250
https://orcid.org/0000-0001-5785-8911