Optimality in the Development of Intestinal Crypts
Intestinal crypts in mammals are comprised of long-lived stem cells and shorter-lived progenies. These two populations are maintained in specific proportions during adult life. Here, we investigate the design principles governing the dynamics of these proportions during crypt morphogenesis. Using op...
Main Authors: | Itzkovitz, Shaul Shalev, Blat, Irene C., Clevers, Hans, van Oudenaarden, Alexander, Jacks, Tyler E., van Oudenaarden, Alexander |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2014
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Online Access: | http://hdl.handle.net/1721.1/92250 https://orcid.org/0000-0001-5785-8911 |
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