T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

T Cell Receptor Internalization from the Immunological Synapse Is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In thi...

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Bibliographic Details
Main Authors: Cemerski, Saso, Delgado, Pilar, Turner, Martin, Heuser, John, Irvine, Darrell J., Huang, Bonnie, Shaw, Andrey, Martinez-Martin, Nuria, Fernandez-Arenas, Elena, Alarcon, Balbino, Bustelo, Xose R.
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/92311

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http://hdl.handle.net/1721.1/92311

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