Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins

Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins

Sequences rich in glutamine (Q) and asparagine (N) residues often fail to fold at the monomer level. This, coupled to their unusual hydrogen-bonding abilities, provides the driving force to switch between disordered monomers and amyloids. Such transitions govern processes as diverse as human protein...

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Bibliographic Details
Main Authors: Halfmann, Randal Arthur, Alberti, Simon, Krishnan, Rajaraman, Lyle, Nicholas, O'Donnell, Charles William, King, Oliver D., Berger, Bonnie, Pappu, Rohit V., Lindquist, Susan
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/92316
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0002-2724-7228

Internet

http://hdl.handle.net/1721.1/92316
https://orcid.org/0000-0003-1307-882X
https://orcid.org/0000-0002-2724-7228

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