Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells

Cancer cells within individual tumors often exist in distinct phenotypic states that differ in functional attributes. While cancer cell populations typically display distinctive equilibria in the proportion of cells in various states, the mechanisms by which this occurs are poorly understood. Here,...

Full description

Bibliographic Details
Main Authors: Fillmore, Christine M., Jiang, Guozhi, Shapira, Sagi D., Tao, Kai, Kuperwasser, Charlotte, Gupta, Piyush, Lander, Eric Steven
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/92332
https://orcid.org/0000-0002-9703-1780