Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

Endogenous T Cell Responses to Antigens Expressed in Lung Adenocarcinomas Delay Malignant Tumor Progression

Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. Here, we describe a system to introduce exogenous antigens into genetically engineered mouse lung cancers to mimic tumor neoantigens. We show that endogenous T cells respon...

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Bibliographic Details
Main Authors: DuPage, Michel J., Mazumdar, Claire, Winslow, Monte M., Bronson, Roderick T., Crowley, Denise G., Chen, Jianzhu, Cheung, Ann, Schmidt, Leah Marie, Jacks, Tyler E.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Elsevier 2014
Online Access:http://hdl.handle.net/1721.1/92334
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-5687-6154
https://orcid.org/0000-0001-9076-8475

Internet

http://hdl.handle.net/1721.1/92334
https://orcid.org/0000-0001-5785-8911
https://orcid.org/0000-0002-5687-6154
https://orcid.org/0000-0001-9076-8475

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