A fully genetically encoded protein architecture for optical control of peptide ligand concentration

Ion channels are among the most important proteins in biology, regulating the activity of excitable cells and changing in diseases. Ideally it would be possible to actuate endogenous ion channels, in a temporally precise and reversible manner, and without requiring chemical cofactors. Here we presen...

Full description

Bibliographic Details
Main Authors: Schmidt, Daniel, Tillberg, Paul W., Chen, Fei, Boyden, Edward
Other Authors: Massachusetts Institute of Technology. Materials Processing Center
Format: Article
Language:en_US
Published: Nature Publishing Group 2014
Online Access:http://hdl.handle.net/1721.1/92343
https://orcid.org/0000-0003-3776-4605
https://orcid.org/0000-0003-0254-4741
https://orcid.org/0000-0002-0419-3351