Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions

Chromatin Loops as Allosteric Modulators of Enhancer-Promoter Interactions

The classic model of eukaryotic gene expression requires direct spatial contact between a distal enhancer and a proximal promoter. Recent Chromosome Conformation Capture (3C) studies show that enhancers and promoters are embedded in a complex network of looping interactions. Here we use a polymer mo...

Full description

Bibliographic Details
Main Authors: Fudenberg, Geoffrey, Doyle, Boryana G., Imakaev, Maksim Viktorovich, Mirny, Leonid A
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/92475
https://orcid.org/0000-0002-0785-5410
https://orcid.org/0000-0002-5320-2728

Internet

http://hdl.handle.net/1721.1/92475
https://orcid.org/0000-0002-0785-5410
https://orcid.org/0000-0002-5320-2728

Similar Items