Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number variants of the SNCA gene locus can cause...

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Bibliographic Details
Main Authors: Flierl, Adrian, Oliveira, Luís M. A., Falomir-Lockhart, Lisandro J., Mak, Sally K., Hesley, Jayne, Soldner, Frank, Arndt-Jovin, Donna J., Jaenisch, Rudolf, Langston, J. William, Jovin, Thomas M., Schüle, Birgitt
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:en_US
Published: Public Library of Science 2014
Online Access:http://hdl.handle.net/1721.1/92476

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http://hdl.handle.net/1721.1/92476

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